Vitamin E
VITAMIN E REDUCES HOT FLUSHES
120 breast cancer survivors, who were going through the
menopause and were advised not to take HRT, were given 800
IU vitamin E daily for one month, then a placebo for another
month. The women had fewer hot flushes when taking vitamin
E.
Berton D.L. et al,
J. CLIN. ONCOLOGY 1998, 16, 495-500
Courtesy AMER. HERB ASSOC. NEWS. 1998, XIV (3)
VITAMIN E INDUCES APOPTOSIS IN ERYTHROLEUKEMIA, PROSTATE,
AND BREAST CANCER CELLS
Scientists at East Carolina University School of Medicine
have shown the effect of vitamin E on a number of cancer
cell lines, including 2 erythroleukemia, a hormone responsive
breast and prostate cancer cell lines. Results showed a
dose-dependent inhibition of cell growth, and apoptosis,
in all cell lines studied, with breast and prostate cancer
cells significantly more sensitive than erythroleukemia
cells.
Sigounas G. et al,
NUTR. CANCER 1997, 28 (1) 30-5
Courtesy POSITIVE HEALTH, March 1998
VITAMIN E AND VITAMIN C SUPPLEMENTATION AND RISK OF ALZHEIMER
DISEASE
A study was carried out to evaluate the association between
the supplementation of vitamins C and E and the incidence
of Alzheimer’s disease in 633 healthy subjects 65
years of age and over. After an average follow-up period
of 4.3 years, 91 subjects had been diagnosed with probable
Alzheimer’s disease. None of the 27 users of vitamin
E or the 23 users of vitamin C supplements had Alzheimer
disease. These data suggest that supplementation with high-dose
vitamins E and C may reduce the risk of Alzheimer disease.
Morris M.C. et al,
ALZHEIMER DISEASE AND ASSOC. DISORDERS 1998, 12, 121-126
VITAMIN E HELPS PREVENT INTELLECTUAL DECLINE
Researchers in Austria studied over 1,700 adults aged between
50 and 75 to test their intellectual capacity. They found
that those with higher levels of vitamin E were less likely
to have low scores in the test. A diet rich in vitamin E
may help prevent free radical damage and slow the progression
of age-related mental decline.
Schmidt, R. et al,
J. AM. GERIATR. SOC. 1998, 46, 1407-10
VITAMIN E MAY REDUCE PROSTATE CANCER INCIDENCE
The results of a large primary-prevention trial in Finnish
men have shown that vitamin E supplements could reduce prostate-cancer
incidence and mortality by one-third in men who smoke. More
than 29,000 male smokers aged 50-69 years were randomly
assigned to receive 50 mg ?-tocopherol, 20 mg ?-carotene,
both, or placebo daily for up to 8 years. At the end of
the study, 246 new cases of prostate cancer and 62 deaths
from the disease had occurred. However, the incidence was
32% lower, and mortality 41% lower in men taking a-tocopherol,
with or without ?-carotene, than in those not taking the
vitamin. ?-carotene non-significantly reduced the risk of
prostate cancer in non-drinkers, but increased the risk
in drinkers, the risk rising with increased alcohol consumption.
?-tocopherol is thought to block tumour progression from
subclinical to clinical phase. The researchers warn, however,
that studies with vitamin supplements are not a good basis
for dietary advice. The bioavailability of supplements may
be quite different from that of natural sources. And such
studies cannot replicate potential interactions with other
beneficial compounds in a natural diet, as occurs between
vitamins C and E in fruit and vegetables.
Bonn,D.
LANCET 1998, 351 (9107) 961
VITAMINS ASSOCIATED WITH LOWER COLON-CANCER RISK
A recent study has shown that supplements of of multivitamins
and vitamin E are associated with a lower risk of colon
cancer. American researchers assessed the frequency, duration,
and daily dose of individual vitamin supplements and multivitamins,
for a ten year interval ending two years before diagnosis
of cancer. After controlling for other predictors of colon-cancer
risk such as intake of dietary vitamins, alcohol, and fibre,
the risk of colon cancer was lower in men and women who
took supplements of vitamins A, C, E, folic acid, calcium,
and multivitamins. But the association was strongest for
vitamin E and multivitamins: people who used multivitamins
daily for the entire 10-year interval had half the risk
of those who had not taken multivitamins. Those who averaged
200 IU or more of vitamin E per day for the 10 years had
a 57% risk reduction compared to non-users.
Macready, N
THE LANCET 1997, 350 (9089) 1452
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