Epidermolysis Bullosa
EB is a genetic disorder, passed on from parents to children,
which causes blistering and shearing of the skin from even
the gentlest friction and sometimes even spontaneously.
There are three major types of EB, Simplex, Dystrophic
and Junctional. These vary from relatively mild to incapacitating,
crippling, and sometimes fatal, disorders. Within these
there are over twenty different sub types of EB, each with
their own characteristic symptoms. The genes responsible
for most of the sub-types of the condition are now known.
Some still await identification.
The genetic defects result in the skin cells collapsing
or skin layers not adhering properly to each other, causing
areas of structural weakness. This fragile skin is particularly
vulnerable to damage from friction, causing the continual
blistering that is the characteristic feature of the condition.
More than skin deep…
Although the effects of EB on the skin are the most visible
symptoms, other parts of the body can be affected. The inside
of the mouth may blister, causing acute discomfort and,
in some cases, restricted opening. The gullet can also be
affected causing difficulties in swallowing and eating.
Other mucosal linings may be affected including the eyes
and anus.
Information Courtesy of:
DEBRA the support group charity of the EB community. DEBRA
UK, the first and largest of 29 national DEBRA organisations
round the world, directly funds a comprehensive specialist
nursing service and medical and scientific research programmes.
Registered Charity No. 284754
DEBRA can be contacted at:
DEBRA House
Wellington Business Park
Dukes Ride
CROWTHORNE RG45 6LS
Tel: 01344 771961
Fax: 01344 762661
Email: DEBRA
For Further information visit the website:
DEBRA
